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Recent articles from top journals
Browse the latest genetics and genomics publications, updated regularly from leading scientific journals.
In vivo site-specific engineering to reprogram T cells
Stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads using a two-vector system of engineered vectors, enabling reprogramming of T cells directly within the body.
Synthetic circuits for cell ratio control
A synthetic genetic circuit made up of recombinase-based cell-fate branching devices enables precise control over the ratios of cell types in an offspring population, advancing synthetic biology capabilities.
Adaptive evolution of gene regulatory networks in mammalian neocortex
The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements that reshape gene regulatory networks.
Biosynthesis of cinchona alkaloids
A combination of isotopic labelling, gene silencing, single-nucleus RNA sequencing and comparative transcriptomics reveal the genes that mediate the biosynthesis of cinchona alkaloids including quinine.
The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation
Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to specifically recognize and degrade target-engaged miRNAs.
Local agricultural transition, crisis and migration in the Southern Andes
In the Uspallata Valley, agriculture was adopted by local populations as evidenced by genetic continuity from earlier hunter-gatherers to farmers; maize-dependent agriculture later collapsed due to climate change.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. This introduces a whole-embryo imaging platform using multiplexed error-robust FISH (weMERFISH).
Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis
Highly pathogenic avian influenza viruses derive from low pathogenic avian influenza viruses. This study identifies the polymerase trapping mechanism behind the insertion of a multibasic cleavage site in the hemagglutinin gene.
Extending the reach of a classic oncogene
Exocytosis exposes Src at the outer surface of cancer cells, poised for therapeutic targeting. This perspective examines the implications of non-canonical Src translocation for cancer therapy.
Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer
Overexpression of the proto-oncogene Src is common to a wide variety of cancers. This work found that Src is noncanonically translocated and inverted onto the cell surface in cancer through autophagolysosomal exocytosis, revealing new therapeutic targets.
Programmable genome editing in human cells using RNA-guided bridge recombinases
Site-specific insertion of gene-sized DNA fragments remains an unmet need in genome editing. IS110-family serine recombinases mediate programmable DNA recombination using a bispecific RNA guide.
Multistep genomics on single cells and live cultures in subnanoliter capsules
Single-cell sequencing methods uncover natural and induced variation between cells. This study demonstrates multistep functional genomic assays on living cells scaled to high throughput in subnanoliter capsules.
High-throughput single-cell omics using semipermeable capsules
Biological systems are inherently complex and heterogeneous. This presents a versatile platform using semipermeable capsules for high-throughput single-cell omics that efficiently probes cellular phenotype and genotype.
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are RNA-guided DNA recombinases that can programmably insert, excise, and invert DNA. This reports the discovery and engineering of bridge recombinases capable of megabase-scale genome rearrangements.